“Actions Imposed by Circumstances”: The Colonial Origins of The Yellow Fever Vaccine Debate, 1940s–1970s
Abstract
Why did the French neurotropic vaccine against yellow fever remain in global use from 1945 to the early 1980s, despite mounting evidence that it could cause fatal encephalitis in small children? This paper investigates debates over the safety and efficacy of the French Dakar-strain vaccine at the World Health Organization (WHO) in the postwar years. French microbiologists argued for retaining the vaccine, citing millions of successful jabs in colonial Africa during World War II. Critics pointed to well-documented postwar cases of serious adverse effects, and the availability of a safer alternative – the Rockefeller 17-D strain. Investigating the WHO-s debate reveals how postwar decisions to retain the Dakar strain as an emergency option, next to the 17-D vaccine, were shaped by prewar epidemiological data. These, in turn were limited by colonial infrastructure and racialized logics of wartime vaccination campaigns. Though the vaccine was supposed to be used only as an emergency alternative, in practice, its ease of use in West African settings made it the default option during outbreaks for decades.
References
Barrett, Alan, and Thomas P. Monath. 2003. “Epidemiology and Ecology of Yellow Fever Virus.” Advances in Virus Research 61: 291–315.
https://doi.org/10.1016/S0065-3527(03)61007-9.
Bazin, Hervé. 2011. Vaccination: A History from Lady Montagu to Genetic Engineering. Montrouge: John Libbey Eurotext.
Bergouniou, Medecin-Capitaine. 1940. Official Report to Chef du Service de Santé à Abidjan, April 17, 1940. IP.SER.3, Archives de l’Institut Pasteur de Dakar (AIP-Dakar).
Borowy, Iris. 2009. Coming to Terms with World Health: The League of Nations Health Organisation 1921–1946. Frankfurt am Main: Peter Lang.
Brès, P. 1971. “Vaccination Programmes in Emergencies.” World Health Organisation (WHO) Expert Committee on Yellow Fever Meeting, March 9–15, 1971, Entebbe. VIR/YF/71.12, WHO-A.
⸻. 1983. “Vaccination.” May 30 – June 3. VIR/YF/83.14, WHO-A.
Brig, Kristin. 2022. “Stabilising Lymph: British East and Central Africa, ‘Tropical’ Climates, and the Search for Effective Smallpox Vaccine Lymph, 1890s–1903.” The Journal of Imperial and Commonwealth History 50(5): 890–914.
https://doi.org/10.1080/03086534.2022.2084933.
Brown, Theodore M., Marcos Cueto, and Elizabeth Fee. 2006. “The World Health Organization and the Transition From ‘International’ to ‘Global’ Public Health.” American Journal of Public Health 96(1): 62–72.
https://doi.org/10.2105/AJPH.2004.050831.
Budd, Lucy, Morag Bell, and Tim Brown. 2009. “Of Plagues, Planes and Politics: Controlling the Global Spread of Infectious Diseases by Air.” Political Geography 28(7): 426–35.
https://doi.org/10.1016/j.polgeo.2009.10.006.
Chambon, L., I. Wone, P. Brès, M. Cornet et al. 1967. “Une épidémie de fièvre jaune au Sénégal en 1965: l’épidémie humaine” [An Epidemic of Yellow Fever in Senegal in 1965: The Human Epidemic]. Bulletin of the World Health Organization 36(1): 113–150.
Chidugu, Simukai. 2020. The Political Life of an Epidemic: Cholera, Crisis and Citizenship in Zimbabwe. Cambridge: Cambridge University Press.
Clark, Hannah Louise. 2016. “Administering Vaccination in Interwar Algeria: Medical Auxiliaries, Smallpox, and the Colonial State in the Communes mixtes.” French Politics, Culture and Society 34(2): 32–56.
https://doi.org/10.3167/fpcs.2016.340203.
Conklin, Alice L. 1997. A Mission to Civilize: The Republican Idea of Empire in France and West Africa, 1895–1930. Stanford: Stanford University Press.
Cooper, Frederick. 2005. Colonialism in Question: Theory, Knowledge, History. Berkeley: University of California Press.
Cornet, M., W. G. Downs, J. Hamon, and H. Saenz. 1971. “Further Research and Investigation.” WHO Expert Committee on Yellow Fever Meeting, March 9–15, Entebbe. VIR/YF/71.8 Rev.1, WHO-A.
Cueto, Marcos, Theodore M. Brown, and Elizabeth Fee. 2019. The World Health Organization: A History. Cambridge: Cambridge University Press.
Darré, H., and P. Mollaret. 1936. “Étude clinique d’un cas de méningo-encéphalite au cours de la séro-vaccination anti-amarile” [Clinical Study of a Case of Meningo-Encephalitis Following Yellow Fever Vaccination]. Bulletin de la Société de Pathologie Exotique. 29: 169–171.
Durieux, Medecin. 1941. Report to M. le Medecine General, July 30, 1941. IP.DIR.5, Archives de l’Institut Pasteur de Dakar (AIP-Dakar).
⸻. n.d. Rapport sur la mission de vaccinations effectué en Cote d'Ivoire. [Report on the Vaccination Mission Undertaken in the Ivory Coast]. IP.DIR.5, Archives de l’Institut Pasteur de Dakar (AIP-Dakar).
Farmer, Paul. 1999. Infections and Inequality: The Modern Plagues. Berkeley: University of California Press.
Findlay, G. M. 1935. “Immunisation contre la fièvre jaune.” 22 January 1935. BPT.Doc.23, Archives de l’Institut Pasteur.
Fox, John P., Simão Luty Kossobudzki, and José Fonseca da Cunha. 1943. “Field Studies on The Immune Response to 17D Yellow Fever Virus: Relation to Virus Substrain, Dose, and Route of Inoculation.” American Journal of Epidemiology 38(2): 113–38.
Governor-General of the AOF. 1940. Address to local Colonial Governors, April 23, 1940, IP.DIR.5, AIP-Dakar.
Hahn, Richard G. 1946. Correspondence with Dr. Strode, November, 7 1946. Folder 404, Box 36, Series 4 IHB/D, RG5, Rockefeller Archive Center (RAC).
Harrison, Mark. 2006. “Disease, Diplomacy and International Commerce: The Origins of International Sanitary Regulation in the Nineteenth Century.” Journal of Global History 1(2): 197–217.
https://doi.org/10.1017/S1740022806000131.
Anon. 1941. Instruction pour l’application de l’arrete du 10 september 1941 rendant obligatoire la vaccination anti-amaryle en Afrique Occidentale Francaise [Instruction for the Implementation of the Decree of 10 September 1941 Making Compulsory Yellow Fever Vaccination in French West Africa]. IP.DIR.5, Archives de l’Institut Pasteur de Dakar (AIP-Dakar).
Kinkela, David. 2011. DDT and the American Century: Global Health, Environmental Politics, and the Pesticide that Changed the World. Chapel Hill: UNC Press.
Lachenal, Guillaume. 2013a. Médecine, comparaisons et échanges inter-impériaux dans le mandat camerounais: une histoire croisée franco-allemande de la mission Jamot [Medicine, Comparisons, and Interimperial Exchanges within the Camerounian Mandate. An Entangled Franco-German History of the Jamot Mission]. Canadian Bulletin of Medical History 30(2): 23–45.
https://utpjournals.press/doi/10.3138/cbmh.30.2.23.
⸻. 2013b. “The Dubaï Stage of Public Health: Global Health in Africa between Past and Future.” Revue Tiers Monde 215: 53–71.
⸻. 2022. The Doctor Who Would Be King. Translated by Cheryl Smeall. Durham: Duke University Press.
Laigret, Jean. 1935. “Immunisation contre la fièvre Jaune” [Vaccination Against Yellow Fever]. La Presse Médicale. 27(Jan): 7.
⸻. 1936. “Au sujet des réactions nerveuses de la vaccination contre la fièvre jaune” [On Neurological Reactions to Yellow Fever Vaccination]. Bulletin de la Société de Pathologie exotique 29: 823–828.
⸻. 1953. “Twenty Years of Yellow Fever Control through Preventive Vaccination.” WHO Expert Committee on Yellow Fever, WHO/YF/19.
⸻. 1957. “Vaccination Against Yellow Fever Using the Dermal Method.” WHO Expert Committee on Yellow Fever Vaccination, WHO/YFV/9.
Lakoff, Andrew. 2017. Unprepared: Global Health in a Time of Emergency. Berkeley: University of California Press.
Löwy, Ilana. 1997. “Epidemiology, Immunology, and Yellow Fever: The Rockefeller Foundation in Brazil, 1923-1939.” Journal of the History of Biology 30(3): 397–417.
⸻. 2001. Virus, moustiques et modernité: la fièvre jaune au Brésil, entre science et politique [Virus, Mosquitoes and Modernity: Yellow Fever in Brazil between Science and Politics]. Paris: Éditions des Archives Contemporaines.
MacNamara, F. N. 1953. “Reactions Following Neurotropic Yellow Fever Vaccine Given by Scarification in Nigeria.” Transactions of the Royal Society of Tropical Medicine and Hygiene 47(3): 199–208.
⸻. 1957. “Yellow Fever Scratch Vaccine (17D strain).” March 19, 1957. WHO/YFV/12, WHO-A.
Mahaffy, A. F. 1954. “The Yellow Fever Situation in Africa.” Bulletin of the World Health Organization 11(3): 319-24.
McNeill, John R. 2010. Mosquito Empires: Ecology and War in the Greater Caribbean, 1620–1914. Cambridge: Cambridge University Press.
Mitchell, Timothy. 2002. The Rule of Experts: Egypt, Techno-Politics, and Modernity. Berkeley: University of California Press.
Monnais, Laurence. 2006. “Preventive Medicine and ‘Mission Civilisatrice’: Uses of the BCG Vaccine in French Colonial Vietnam between the Two World Wars,” The International Journal of Asia-Pacific Studies 2(1): 40–66.
⸻. 2019. The Colonial Life of Pharmaceuticals: Medicines and Modernity in Vietnam. Cambridge: Cambridge University Press.
Morefield, Heidi. 2019. “‘More with Less’: Commerce, Technology, and International Health at USAID, 1961-1981.” Diplomatic History 43(4): 618–43
https://doi.org/10.1093/dh/dhz024.
Naono, Atsuko. 2009. State of Vaccination: The Fight Against Smallpox in Colonial Burma. Hyderabad: Orient Blackswan.
Packard, Randall. 1997. “Malaria Dreams: Postwar Visions of Health and Development in the Third World.” Medical Anthropology 17(3): 279–296.
https://doi.org/10.1080/01459740.1997.9966141.
⸻. 2016. A History of Global Health: Interventions into the Lives of Other Peoples. Baltimore: Johns Hopkins University Press.
Pearson, Jessica Lynne. 2018. The Colonial Politics of Global Health: France and the United Nations in Postwar Africa. Cambridge, MA: Harvard University Press.
Pellissier, Aimé, and Emile Trinquier. 1953. “Isolement d’un virus encéphalomyélitique au cours d’une petite épidémie de « poliomyélite clinique » à Brazzaville: étude expérimentale et épidémiologique” [Isolation of an Encephomyelitic Virus During a Small Epidemic of “Clinically Presenting Poliomyelitis” in Brazzaville: Experimental and Epidemiological Study] Annales de l’Institut Pasteur 85(3): 316-27.
Peltier, Maurice. n.d. Vaccination antiamarile, simple ou associée a la vaccination antivariolique, des populations de l’Afrique Occidentale Francaise. . . [Mixed Vaccination Against Yellow Fever and Smallpox in Indigenous Populations of Senegal. . .]. IP.DIR.5, Archives de l’Institut Pasteur de Dakar (AIP-Dakar).
⸻. 1946. “Report to the UNRRA Expert Commission on Quarantine. Dakar Yellow Fever Vaccine. An Experiment to Determine the Immunizing Powers of Yellow-Fever Vaccine Produced by the Pasteur Institute at Dakar.” Epidemiological Information Bulletin 2: 618.
Peltier, Maurice, Camille Durieux, H. Jonchère, and Émile Arquié. n.d. “Vaccination mixte contre la Fièvre Jaune et la Variole sur les populations indigènes du Sénégal.” IP.DIR.5, Archives de l’Institut Pasteur de Dakar (AIP-Dakar).
Penthier, R. 1957. “The Production and Use of Yellow Fever Scratch Vaccine.” March 8, 1957. WHO/YFV/6, WHO-A.
Plotkin, Stanley A., ed. 2011. History of Vaccine Development. New York: Springer.
Proctor, Robert N., and Londa Schiebinger, eds. 2008. Agnotology: The Making and Unmaking of Ignorance. Stanford: Stanford University Press.
Redfield, Peter. 2013. Life in Crisis. Berkeley: University of California Press.
Rigollet, Pierre-Émile-Jean. 1939. Prophylaxie de la fièvre Jaune Notamment par la Vaccination anti-Amarile. [Prophylaxis Against Yellow Fever, Notably Through Yellow Fever Vaccination]. Bordeaux: Imprimerie Delmas.
Robert, Medecin-Colonel. 1941. Circular, June 23, 1941. IP.DIR.5, Archives de l’Institut Pasteur de Dakar (AIP-Dakar).
Russell, Edmund. 2001. War and Nature: Fighting Humans and Insects with Chemicals from World War 1 to Silent Spring. Cambridge: Cambridge University Press.
Schneider, William H. 2009. “Smallpox in Africa During Colonial Rule.” Medical History 53(2): 193–227.
https://doi.org/10.1017/S002572730000363X.
Stefanopolou, Georges. 1934. Correspondence with Dr. Sawyer, Oct 16, 1934. Folder 313, Box 28, Series 4 IHB/D, RG 5, Rockefeller Archive Center (RAC).
Stepan, Nancy Leis. 2011. Eradication: Ridding the World of Diseases Forever? Chicago: Chicago University Press.
Stock, P. G. 1945. “The International Sanitary Convention, 1944.” Proceedings of the Royal Society of Medicine 38: 309–316.
https://treaties.fcdo.gov.uk/data/Library2/pdf/1946-TS0058.pdf.
Stones, P. B., and F. N. MacNamara. 1955. “Encephalitis Following Neurotropic Yellow Fever Vaccine Administered by Scarification in Nigeria: Epidemiological and Laboratory Studies.” Transactions of the Royal Society of Tropical Medicine and Hygiene 49(2): 176–86.
https://doi.org/10.1016/0035-9203(55)90044-4.
Stowman, Knud. n.d. “Yellow Fever Endemic Zones and the Vote of the Seventh World Health Assembly.” WHO2/EQ/2/47, WHO-A.
Stuart, G. 1953. “Encephalitis in Man Following the Use of Yellow Fever Immunizing Vaccines: A Review of the Literature.” WHO/YF/6, WHO-A.
UNRRA [United Nations Relief and Rehabilitation Administration]. 1945. “Standards for the Manufacture and Control of Yellow Fever Vaccine,” UNRRA Epidemiological Information Bulletin 1(9): 365-70.
UNRRA [United Nations Relief and Rehabilitation Administration]. 1950. “Report to the U.N.R.R.A. Expert Commission on Euarantine. Dakar Yellow Fever Vaccine,” Epidemiological Information Bulletin, 2, 1946, 618.
UN Treaty. 1944. “International Sanitary Convention for Aerial Navigation, 1944, Modifying the International Sanitary Convention for Aerial Navigation of 12 April 1933.” Washington, DC, December 15, 1944, UN Treaty Series 15(106): 246-308.
Anon. n.d. Vaccination antiamarile, simple ou associée a la vaccination antivariolique. . . [Yellow Fever Vaccination, Simple or Combined with Smallpox Vaccination]. IP.DIR.5, Archives de l’Institut Pasteur de Dakar (AIP-Dakar).
Velmet, Aro. 2019. “The Making of a Pastorian Empire: Tuberculosis and Bacteriological Technopolitics in French Colonialism and International Science, 1890–1940.” Journal of Global History 14(2): 199–217.
https://doi.org/10.1017/S1740022819000032.
⸻. 2020. Pasteur’s Empire: Bacteriology and Politics in France, Its Colonies, and the World. New York: Oxford University Press.
Vernes, Arthur, and Rene Trautmann. 1940. Observations Générales a la Suite d'une Visite de Prospection en AOF [General Observation After a Prospecting Visit to French West Africa] (Dakar: Gouvernement Général, 1940), 2013 ZK 005 161, SHD-Toulon.
White, Alexandre. 2023. Epidemic Orientalism: Race, Capital, and the Governance of Infectious Disease. Stanford: Stanford University.
World Health Organization (WHO). 1950. Report of the Yellow Fever Panel. March 28, 1950. WHA3/12, WHO-A.
⸻. 1957. Expert Committee on Yellow Fever Vaccine, First Report. WHO/TRS/136, WHO-A.
⸻. 1959. Requirements for biological substances. WHO/TRS/179, WHO-A.
⸻. 1971. “Expert Committee on Yellow Fever Vaccine, Third Report.” World Health Organization Technical Report Series 479: 1–56.
⸻. 2023. “World Health Organization Model List of Essential Medicines – 23rd List, 2023.” In The Selection and Use of Essential Medicines 2023: Executive Summary of the Report of the 24th WHO Expert Committee on the Selection and Use of Essential Medicines, 24 – 28 April 2023.
⸻. 1950. Boyd, J. S. K. to G. Stuart. Letter April 11, 1950. WHO2/EQ/5/1, WHO-A.
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